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代表論文

  1. Okuno# H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF, Bito# H. Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ. Cell, 149, 886-898 (2012).
  2. Kawashima* T, Okuno* H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S, Worley P, Bito H. A synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc. Natl. Acad. Sci. USA, 106: 316–321 (2009).
  3. Tokuyama* W, Okuno* H, Hashimoto T, Li Y-X, Miyashita Y. BDNF upregulation during declarative memory formation in the monkey inferotemporal cortex. Nature Neurosci., 3: 1134–1142 (2000).

原著論文・英文総説

2025

  1. Kiyama Y, Suzuki Y, Haraguchi M, Oe Y, Daitoku Y, Higa N, Irie Y, Suzuki T, Imayoshi I, Kakeyama M, Okuno# H. A simple method that doubles learning speed for mice in touchscreen-based visual discrimination. Sci Rep. 15: 43133 (2025).
  2. Ageta-Ishihara N, Fukazawa Y, Arima-Yoshida F, Okuno H, Ishii Y, Takao K, Konno K, Fujishima K, Ageta H, Hioki H, Tsuchida K, Sato Y, Kengaku M, Watanabe M, Watabe AM, Manabe T, Miyakawa T, Inokuchi K, Bito H, Kinoshita M. Septin 3 regulates memory and L-LTP-dependent extension of endoplasmic reticulum into spines. Cell Rep. 44: 115352 (2025).
  3. Wagatsuma N, Terada Y, Okuno H, Ageta-Ishihara N. Local connections among excitatory neurons underlie characteristics of enriched environment exposure-induced neuronal response modulation in layers 2/3 of the mouse V1. Front Syst Neurosci. 19: 1525717 (2025).

2024

  1. Kaneko T, Oura A, Imai Y, Kusumoto-Yoshida I, Kanekura T, Okuno H, Kuwaki T, Kashiwadan H. Orexin neurons play contrasting roles in itch and pain neural processing via projecting to the periaqueductal gray. Communications Biology, 7: 290 (2024).

2023

  1. Takakura M, Lam YH, Nakagawa R, Ng MY, Hu X, Bhargava P, Alia AG, Gu Y, Wang Z, Ota T, Kimura Y, Morimoto N, Osakada F, Lee AY, Leung D, Miyashita T, Du J, Okuno H, Hirano Y. Differential second messenger signaling via dopamine neurons bidirectionally regulates memory retention. Proc Natl Acad Sci, 20: e2304851120 (2023).
  2. Pagano R, Salamian A, Zielinski J, Beroun A, Nalberczak-Skora M, Skonieczna E, Ca?y A, Tay N, Banaschewski T, Desrivieres S, Grigis A, Garavan H, Heinz A, Bruhl R, Martinot JL, Martinot MP, Artiges E, Nees F, Orfanos DP, Poustka L, Hohmann S, Frohner JH, Smolka MN, Vaidya N, Walter H, Whelan R; IMAGEN consortium; Kalita K, Bito H, Muller# CP, Schumann# G, Okuno# H, Radwanska# K. Arc controls alcohol cue relapse by a central amygdala mechanism. Molecular Psychiatry, 28: 733–745.

2022

  1. Oota-Ishigaki A, Takao K, Yamada D, Sekiguchi M, Itoh M, Koshidata Y, Abe M, Natsume R, Kaneko M, Adachi T, Kaizuka T, Suzuki N, Sakimura K, Okuno H, Wada K, Mishina M, Miyakawa T, Hayashi T. Prolonged contextual fear memory in AMPA receptor palmitoylation-deficient mice. Neuropsychopharmacology, 47: 2150–2159.
  2. Mahringer D, Zmarz P, Okuno H, Bito H, Keller GB. Functional correlates of immediate early gene expression in mouse visual cortex. Peer Community Journal, 2: e45.
  3. Goto F, Kiyama# Y, Ogawa I, Okuno H, Ichise T, Ichise H, Anai M, Kodama T, Yoshida N, Bito H, Manabe# T. Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area. Molecular Psychiatry, 27: 1694–1703.
  4. Sato M, Sato-Yamamoto N, Wakita A, Haraguchi M, Shimonishi M, Okuno# H. Direct injection of recombinant AAV-containing solution into the oviductal lumen of pregnant mice. Int J Mol Sci. 23: 4897.
  5. Niu M, Kasai A, Tanuma M, Seiriki K, Igarashi H, Kuwaki T, Nagayasu K, Miyaji K, Ueno H, Tanabe W, Seo K, Yokoyama R, Ohkubo J, Ago Y, Hayashida M, Inoue KI, Takada M, Yamaguchi S, Nakazawa T, Kaneko S, Okuno H, Yamanaka A, Hashimoto H. Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses. Sci Adv. 8: eabi6375.

2021

  1. Ohnishi* T, Kiyama* Y, Arima-Yoshida F, Kadota M,Ichikawa T, Yamada K, Watanabe A, Ohba H, Tanaka K, Nakaya A, Horiuchi Y, Iwayama Y, Toyoshima M, Ogawa I, Shimamoto-Mitsuyama C, Maekawa M, Balan S, Arai M, Miyashita M, Toriumi K, Nozaki Y, Kurokawa R, Suzuki K, Yoshikawa A, Toyota T, Hosoya T, Okuno H, Bito H, Itokawa M, Kuraku S, Manabe T, Yoshikawa T. Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathophysiology of schizophrenia. EMBO Mol Med, 13: e12574.
  2. Takakura M, Nakagawa R, Ota T, Kimura Y, Okuno H, Hirano Y. Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila. Nat Commun, 12: 628.

2020

  1. Fujita H, Oikawa R, Hayakawa M, Tomoike F, Kimura Y, Okuno H, Hatashita Y, Oliveros CF, Bito H, Ohshima T, Tsuneda S, Abe H, Inoue T. Quantification of native mRNA dynamics in living neurons using fluorescence correlation spectroscopy and reduction-triggered fluorescent probes. J Biol Chem, 295: 7923–7940.

2019

  1. Suzuki AZ, Sekine R, Takeda S, Aikawa R, Shiraishi Y, Hamaguchi T, Okuno H, Tamamura H, Furuta T. A clickable caging group as a new platform for modular caged compounds with improved photochemical properties. Chem Commun (Camb), 55: 451–454.
  2. Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Kobayashi K, Miyamichi K, Okuno H, Bito H, Sakurai Y, Yamaguchi M, Mori K, Manabe H. GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice. Sci Rep, 9: 7132.
  3. Itoh M, Okuno H, Yamada D, Yamashita M, Abe M, Natsume R, Kaizuka T, Sakimura K, Hoshino M, Mishina M, Wada K, Sekiguchi M, Hayashi T. Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C-terminal palmitoylation-deficient mice. Neuropsychopharmacol Rep. 9: 61–66.
  4. Kikuchi K, Ihara D, Fukuchi M, Tanabe H, Ishibashi Y, Tsujii J, Tsuda M, Kaneda M, Sakagami H, Okuno H, Bito H, Yamazaki Y, Ishikawa M, Tabuchi A. Involvement of SRF coactivator MKL2 in BDNF-mediated activation of the synaptic activity-responsive element in the Arc gene. J Neurochem. 148: 204–218.

2018

  1. Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T, Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T. Deficiency of AMPAR-Palmitoylation Aggravates Seizure Susceptibility. J Neurosci. 38: 10220–10235.
  2. Chawla MK, Gray DT, Nguyen C, Dhaliwal H, Zempare M, Okuno H, Huentelman MJ, Barnes CA. Seizure-induced Arc mRNA expression thresholds in rat hippocampus and perirhinal cortex. Front Syst Neurosci, 12: 53.
  3. Attardo A, Lu J, Kawashima T, Okuno H, Fitzgerald JE, Bito H, Schnitzer MJ. Long-term consolidation of ensemble neural plasticity patterns in hippocampal area CA1. Cell Rep, 25: 640–650.
  4. Yamada M, Suzuki Y, Nagasaki S, Okuno H, Imayoshi I. Light control of the Tet-gene expression system in mammalian cells. Cell Rep, 25: 487–500.
  5. El-Boustani S, Ip JPK, Breton-Provencher V, Knott GW, Okuno H, Bito H, Sur M. Locally coordinated synaptic plasticity shapes cell-wide plasticity of visual cortex neurons in vivo. Science, 360: 1349–1354.
  6. Okuno H, Minatohara K, Bito H. Inverse synaptic tagging: An inactive synapse-specific mechanism to capture activity-induced Arc/arg3.1 and to locally regulate spatial distribution of synaptic weights. Semin Cell Dev Biol, 77: 43–50.
  7. Nishiguchi KM, Fujita K, Tokashiki N, Komamura H, Takemoto-Kimura S, Okuno H, Bito H, Nakazawa T. Retained plasticity and substantial recovery of rod-mediated visual acuity at the visual cortex in blind adult mice with retinal dystrophy. Mol Ther. 26: 2397–2406.
  8. Steward O, Matsudaira-Yee K, Rarris S, Salgado-Pirbhoy P, Worely P, Okamura K, Okuno H, Bito H. Delayed degradation and impaired dendritic delivery of intron-lacking EGFP-Arc/Arg3.1 mRNA in EGFP-Arc transgenic mice. Front Mol Neurosci, 10: 435.

2017

  1. Honjoh S, de Vivo L, Bito H, Okuno H, Tononi G, Cirelli C. Higher Arc nucleus-to-cytoplasm ratio during sleep in the superficial layers of the mouse cortex. Front Neural Circuits, 11: 60.
  2. Inokuchi K, Imamura F, Takeuchi H, Kim R, Okuno H, Nishizumi H, Bito H, Kikusui T, Sakano H. Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odor-induced attractive social responses. Nat Commun, 8: 15977.
  3. Jenks KR, Kim T, Pastuzyn ED, Okuno H, Taibia AV, Bito H, Bear MF, Jason SD. Arc restores juvenile plasticity in adult mouse visual cortex. Proc. Natl. Acad. Sci. USA, 114: 9182–9187.

2016

  1. Hirano Y, Ihara K, Masuda T, Yamamoto T, Iwata I, Takahashi A, Awata H, Nakamura N, Takakura M, Suzuki Y, Horiuchi J, Okuno H H, Saitoe M. Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies. Nat Commun, 7: 13471.
  2. Minatohara K, Akiyoshi M, Okuno# H. Role of immediate-early genes in synaptic plasticity and neuronal ensembles underlying the memory trace. Front. Mol. Neurosci., 8: 78.

2015

  1. Yamamoto K, Tanei Z, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno LE, Fukayama M, Bito H, Cirrito JR, Holtzman DM, Deisseroth K, Iwatsubo T. Chronic optogenetic activation augments Aβ pathology in a mouse model of Alzheimer disease. Cell Rep, 11: 859–865.
  2. Fukuchi M, Tabuchi A, Kuwana Y, Watanabe S, Inoue M, Takasaki I, Izumi H, Tanaka A, Inoue R, Mori H, Komatsu H, Takamori H, Okuno H, Bito H, Tsuda M. Neuromodulatory effect of Gαs- or Gαq-coupled GPCR on NMDAR. J Neurosci, 35: 5606–5624.
  3. Vousden DA, Epp J, Okuno H, Nieman BJ, van Eede M, Dazai J, Ragan T, Bito H, Frankland PW, Lerch JP, Henkelman RM. Whole-brain mapping of behaviourally induced neural activation in mice. Brain Struct. Funct., 220: 2043–2057.

2014 以前 (抜粋)

  1. Kawashima T, Okuno H, Bito H. A new era for functional labeling of neurons: activity-dependent promoters have come of age. Front. Neural Circuits, 8: 37 (2014).
  2. Kawashima T, Kitamura K, Suzuki K, Nonaka M, Kamijyo S, Takemoto-Kimura S, Kano M, Okuno H, Ohki K, Bito H. Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE. Nat Methods, 10: 889–895 (2013).
  3. Mikuni T, Uesaka N, Okuno H, Hirai H, Deisseroth K, Bito H, Kano K. Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum. Neuron, 78: 1024–1035 (2013).
  4. Tse D, Takeuchi T, Kakeyama M, Kajii Y, Okuno H, Tohyama C, Bito H, Morris RGM. Schema-dependent gene activation and memory encoding in neocortex. Science, 333: 891–895 (2011).
  5. Okuno H. Regulation and function of immediate-early genes in the brain: beyond neuronal activity markers. Neuroscience Res., 69: 175–186 (2011).
  6. Redondo RL, Okuno H, Spooner PA, Frenguelli BG, Bito H, Morris RGM: Synaptic tagging and capture: differential role of distinct calcium-calmodulin kinases in protein synthesis-dependent long-term potentiation. J. Neurosci, 30:4981–4989 (2010).
  7. Chowdhury S, Shepherd JD, Okuno H, Lyford G, Petralia RS, Plath N, Kuhl D, Huganir RL, Worley PF. Arc interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron, 52: 445–459 (2006).
  8. Tokuyama* W, Okuno* H, Hashimoto T, Li Y-X, Miyashita Y. BDNF upregulation during declarative memory formation in the monkey inferotemporal cortex. Nature Neurosci., 3: 1134–1142 (2000).

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