＜代表論文＞
1. Okuno, H., Akashi, K., Ishii, Y., Yagishita-Kyo, N., Suzuki, K., Nonaka, M., Kawashima, T., Fujii, H., Takemoto-Kimura, S., Abe, M., Natsume, R., Chowdhury, S., Sakimura, K., Worley, P.F., and Bito, H. Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ. Cell, 149: 886-898,(2012).
2. Kawashima*, T., Okuno*, H., Nonaka, M., Adachi-Morishima, A., Kyo, N., Okamura, M., Takemoto-Kimura, S., Worley, P., Bito, H. A synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons, Proc. Natl. Acad. Sci. USA, 106: 316-321, (2009).
3. Tokuyama*, W., Okuno*, H., Hashimoto, T., Li, Y-X. and Miyashita, Y. BDNF upregulation during declarative memory formation in the monkey inferotemporal cortex. Nature Neurosci., 3, 1134-1142, (2000).
4. Okuno, H., Tokuyama, W., Li, Y-X., Hashimoto, T. and Miyashita, Y. Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito-temporo-hippocampal pathway in adult macaque monkeys. J. Comp. Neurol., 408: 378-398, (1999).
5. Okuno, H. and Miyashita, Y. Expression of the transcription factor Zif268 in the temporal cortex of monkeys during visual paired associate learning. Eur. J. Neurosci., 8: 2118-2128, (1996).
＜主な和文総説＞
奥野浩行、尾藤晴彦. 核からシナプスへの分子ターゲティング機構の解明－神経回路の長期可塑性を制御するArcタンパク質のケーススタディー, 生化学、 86: 18-27, (2014).
奥野浩行. 記憶の分子機構：神経細胞の情報伝達効率を調節するメカニズム Brain and Nerve, 65: 1171-1178. (2013)
奥野浩行. シナプス活動によって誘導されるArcの発現制御機構. 生化学, 82: 841-846, (2010).
奥野浩行、川島尚之、野中美応、尾藤晴彦.
シナプスから核へのシグナリング：シナプス可塑性を長期化する分子機構.
細胞工学 28: 894-899, (2009).
奥野浩行、竹本-木村さやか、大前彰吾、岡村理子、石原奈津実、尾藤晴彦.
シナプス活動による遺伝子発現制御. 蛋白質核酸酵素 49: 411-418,(2004).
奧野浩行、篠本滋. 記憶の情報表現. 科学, 67: 689-698, (1997).
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＜原著論文&英文総説＞
[2023]
Pagano R, Salamian A, Zielinski J (中略 25人), Muller# CP, Schumann# G, Okuno# H, and Radwanska# K, Arc controls alcohol cue relapse by a central amygdala mechanism
Molecular Psychiatry, 28:733-745 # Equal contribution (doi.org/10.1038/s41380-022-01849-4)
[2022]
Oota-Ishigaki A, Takao K, Yamada D, Sekiguchi M, Itoh M, Koshidata Y, Abe M, Natsume R, Kaneko M, Adachi T, Kaizuka T, Suzuki N, Sakimura K, Okuno H, Wada K, Mishina M, Miyakawa T, Hayashi T. Prolonged contextual fear memory in AMPA receptor palmitoylation-deficient mice. Neuropsychopharmacology, 47:2150-2159 (doi.org/10.1038/s41386-022-01347-9)
Mahringer D, Zmarz P, Okuno H, Bito H, Keller GB. Functional correlates of immediate early gene expression in mouse visual cortex. Peer Community Journal, 2:article e45 (doi.org/10.24072/pci.neuro.100005)
Goto F, Kiyama* Y, Ogawa I, Okuno H, Ichise T, Ichise H, Anai M, Kodama T, Yoshida N, Bito H, Manabe* T. Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area.
Molecular Psychiatry, 27:1694-1703. (doi.org/10.1038/s41380-021-01408-3) *, Corresponding authors
Sato M, Sato-Yamamoto N, Wakita A, Haraguchi M, Shimonishi M, Okuno H. Direct injection of recombinant AAV-containing solution into the oviductal lumen of pregnant mice caused in situ infection of both preimplantation embryos and oviductal epithelium. Int J Mol Sci. 23:4897. (doi.org/10.3390/ijms23094897)
Niu M, Kasai A, Tanuma M, Seiriki K, Igarashi H, Kuwaki T, Nagayasu K, Miyaji K, Ueno H, Tanabe W, Seo K, Yokoyama R, Ohkubo J, Ago Y, Hayashida M, Inoue KI, Takada M, Yamaguchi S, Nakazawa T, Kaneko S, Okuno H, Yamanaka A, Hashimoto H. Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses. Sci Adv. 8:eabi6375. (doi:10.1126/sciadv.abi6375)
[2021]
Ohnishi# T, Kiyama# Y, Arima-Yoshida# F, Kadota# M,Ichikawa T, Yamada K, Watanabe A, Ohba H, Tanaka K, Nakaya A, Horiuchi Y, Iwayama Y, Toyoshima M, Ogawa I, Shimamoto-Mitsuyama C, Maekawa M, Balan S, Arai M, Miyashita M, Toriumi K, Nozaki Y, Kurokawa R, Suzuki K, Yoshikawa A, Toyota T, Hosoya T, Okuno H, Bito H, Itokawa M, Kuraku S, Manabe T, Yoshikawa T.
Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathophysiology of schizophrenia. EMBO Mol Med, 13:e12574. (doi: 10.15252/emmm.202012574). #These authors contributed equally to this work.
Takakura M, Nakagawa R, Ota T, Kimura Y, Okuno H, Hirano Y. Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila. Nat Commun, 12:628. (doi: 10.1038/s41467-021-20898-x)
[2020]
Fujita H, Oikawa R, Hayakawa M, Tomoike F, Kimura Y, Okuno H, Hatashita Y, Oliveros CF, Bito H, Ohshima T, Tsuneda S, Abe H, Inoue T. Quantification of native mRNA dynamics in living neurons using fluorescence correlation spectroscopy and reduction-triggered fluorescent probes. J Biol Chem 295:7923-7940. (doi: 10.1074/jbc.RA119.010921)
[2019]
Suzuki AZ, Sekine R, Takeda S, Aikawa R, Shiraishi Y, Hamaguchi T, Okuno H, Tamamura H, Furuta T. A clickable caging group as a new platform formodular caged compounds with improvedphotochemical properties. Chem Commun (Camb), 55(4):451-454. (doi: 10.1039/c8cc07981a)
Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Kobayashi K, Miyamichi K, Okuno H, Bito H, Sakurai Y, Yamaguchi M, Mori K, Manabe H. GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice. Sci Rep, 9:7132. (doi: 10.1038/s41598-019-43580-1)
Itoh M, Okuno H, Yamada D, Yamashita M, Abe M, Natsume R, Kaizuka T, Sakimura K, Hoshino M, Mishina M, Wada K, Sekiguchi M, Hayashi T. Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C-terminal palmitoylation-deficient mice. Neuropsychopharmacol Rep. 9(1):61-66. (doi: 10.1002/npr2.12044)
Kikuchi K, Ihara D, Fukuchi M, Tanabe H, Ishibashi Y, Tsujii J, Tsuda M, Kaneda M, Sakagami H, Okuno H, Bito H, Yamazaki Y, Ishikawa M, Tabuchi A.
Involvement of SRF coactivator MKL2 in BDNF-mediated activation of the synaptic activity-responsive element in the Arc gene. J Neurochem. 148:204-218. (doi: 10.1111/jnc.14596)
[2018]
Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T, Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T. Deficiency of AMPAR-Palmitoylation Aggravates Seizure Susceptibility.J Neurosci. 38(47):10220-10235. (doi: 10.1523/JNEUROSCI.1590-18.2018)
Chawla MK, Gray DT, Nguyen C, Dhaliwal H, Zempare M, Okuno H, Huentelman MJ, Barnes CA. Seizure-induced Arc mRNA expression thresholds in rat hippocampus and perirhinal cortex. Front Syst Neurosci, 12:53. (doi: 10.3389/fnsys.2018.00053)
Attardo A, Lu J. Kawashima T, Okuno H, Fitzgerald JE, Bito H, Schnitzer MJ. Long-term consolidation of ensemble neural plasticity patterns in hippocampal area CA1, Cell Rep, 25:640-650, 2018. (doi: 10.1016/j.celrep.2018.09.064).
Yamada M, Suzuki Y, Nagasaki S, Okuno H, Imayoshi I. Light control of the Tet-gene expression system in mammalian cells. Cell Rep, 25:487-500. (doi: 10.1016/j.celrep.2018.09.026)
El-Boustani S, Ip JPK, Breton-Provencher V, Knott GW, Okuno H, Bito H, Sur M. Locally coordinated synaptic plasticity shapes cell-wide plasticity of visual cortex neurons in vivo. Science, 360:1349-1354. (doi: 10.1126/science.aao0862)
Okuno, H., Minatohara, K,, Bito, H. Inverse synaptic tagging: An inactive synapse-specific mechanism to capture activity-induced Arc/arg3.1 and to locally regulate spatial distribution of synaptic weights. Semin Cell Dev Biol, 77: 43-50. (DOI: 10.1016/j.semcdb.2017.09.025)
Nishiguchi KM, Fujita K, Tokashiki N, Komamura H, Takemoto-Kimura S, Okuno H, Bito H, Nakazawa T. Retained plsticity and substantial recovery of rod-mediated visual acuity at the visual cortex in blind adult mice with retinal dystrophy. Mol Ther. 26(10):2397-2406. (doi: 10.1016/j.ymthe.2018.07.012)
Steward, O., Matsudaira-Yee, K., Rarris, S., Salgado-Pirbhoy, P., Worely, P., Okamura, K., Okuno, H., Bito, H. Delayed degradation and impaired dendritic delivery of intron-lacking EGFP-Arc/Arg3.1 mRNA in EGFP-Arc transgenic mice. Front Mol Neurosci, 10:435. (DOI: 10.3389/fnmol.2017.00435)
[2017]
Honjoh, S., de Vivo, L., Bito, H., Okuno, H., Tononi, G., Cirelli, C. Higher Arc nucleus-to-cytoplasm ratio during sleep in the superficial layers of the mouse cortex. Front Neural Circuits, 11:Article 60. (DOI: 10.3389/fncir.2017.00060)
Inokuchi, K., Imamura, F., Takeuchi, H., Kim, R., Okuno, H., Nishizumi, H., Bito, H., Kikusui, T., Sakano, H. Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odor-induced attractive social responses. Nat Commun, 8: 15977. (DOI: 10.1038/ncomms15977)
Jenks, KR., Kim, T., Pastuzyn, ED., Okuno, H., Taibia, AV., Bito, H., Bear, MF., Jason. SD. Arc restores juvenile plasticity in adult mouse visual cortex. Proc. Natl. Acad. Sci. USA, 114:9182-9187. (doi: 10.1073/pnas.1700866114).
[2016]
Hirano, Y., Ihara, K., Masuda, T., Yamamoto T., Iwata, I., Takahashi, A., Awata, H., Nakamura, N., Takakura, M., Suzuki, Y., Horiuchi, J., Okuno, H., Saitoe, M. Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies. Nat Commun, 7: 13471. (DOI10.1038/ncomms13471)
Minatohara, K., Akiyoshi, M., Okuno, H., Role of immediate-early genes in synaptic plasticity and neuronal ensembles underlying the memory trace. Front. Mol. Neurosci., 8: 78.(doi:10.3389/fnmol.2015.00078)
[2015]
Yamamoto, K., Tanei, Z., Hashimoto, T., Wakabayashi, T., Okuno, H., Naka, Y., Yizhar, O., Fenno, LE., Fukayama, M., Bito, H., Cirrito, JR., Holtzman, DM., Deisseroth, K., Iwatsubo, T. Chronic optogenetic activation augments Abeta pathology in a mouse model of Alzheimer disease. Cell Rep, 11: 859-865. (doi:10.1016/j.celrep.2015.04.017）
Fukuchi, M., Tabuchi, A., Kuwana, Y., Watanabe S., Inoue, M., Takasaki, I., Izumi, H., Tanaka, A., Inoue, R., Mori, H., Komatsu, H., Takamori, H., Okuno, H., Bito, H., Tsuda, M. Neuromodulatory effect of Gαs- or Gαq-coupled GPCR on NMDAR selectively activates the NMDAR/Ca2+/calcineurin/CREB-regulated transcriptional coactivator 1 (CRTC1) pathway to effectively induce Bdnf expression in neurons. J Neurosci, 35:5606-5624. (doi: 10.1523/JNEUROSCI.3650-14.2015)
Fukuchi, M., Nakashima, F., Tabuchi, A.,Shimotori, M., Tatsumi, S., Okuno, H., Bito, H., Tsuda, M. Class I Histone deacetylase-mediated repression of the proximal promoter of the activity-regulated cytoskeleton-associated protein gene regulates its response to brain-derived neurotrophic factor. J Biol Chem. 290:6825-36. (doi:10.1074/jbc.M114.617258）
Vousden, DA., Epp, J., Okuno, H., Nieman, BJ., van Eede, M., Dazai, J., Ragan, T., Bito, H., Frankland, PW., Lerch, JP., Henkelman, RM. Whole-brain mapping of behaviourally induced neural activation in mice. Brain Struct. Funct., 220, 2043-2057.(doi:10.1007/s00429-014-0774-0)
[2014]
Kawashima T, Okuno H, Bito H. A new era for functional labeling of neurons: activity-dependent promoters have come of age. Front. Neural Circuits, 8: 37（doi: 10.3389/fncir.2014.00037）
Nonaka M, Fujii H, Kim R, Kawashima T, Okuno H, Bito H. Untangling the two-way signalling route from synapses to the nucleus, and from the nucleus back to the synapses. Philos Trans R Soc Lond B Biol Sci. 369 (1633): 20130150. (DOI: 10.1098/rstb.2013.0150)
[2013]
Kawashima, T., Kitamura, K., Suzuki, K., Nonaka, M., Kamijyo, S., Takemoto-Kimura, S., Kano, M., Okuno, H., Ohki, K, and Bito, H. Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE. Nat Methods, 10, 889-895. (DOI: 10.1038/nmeth.2559)
Mikuni, T., Uesaka, N., Okuno, H., Hirai, H., Deisseroth, K., Bito, H. and Kano, K. Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum. Neuron, 78, 1024-1035. (DOI: 10.1016/j.neuron.2013.04.036)
Fujii, H., Inoue, M., Okuno, H., Sano, Y., Takemoto-Kimura, S., Kitamura K., Kano, M., and Bito, H. Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and Calcineurin. Cell Reports, 3, 978-987. (DOI: 10.1016/j.celrep.2013.03.033)
[2012]
Okuno, H., Akashi, K., Ishii, Y., Yagishita-Kyo, N., Suzuki, K., Nonaka, M., Kawashima, T., Fujii, H., Takemoto-Kimura, S., Abe, M., Natsume, R., Chowdhury, S., Sakimura, K., Worley, P.F., and Bito, H. Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ. Cell, 149, 886-898.
Kim* R, Okuno* H, Bito H. Deciphering the molecular rules governing synaptic targeting of the memory related protein Arc. Commun. Integr. Biol., 5, 493-495.
Endo, T., Kakeyama, M., Uemura, Y., Haijima, A., Okuno, H., Bito, H., Tohyama, C. Executive Function Deficits and Low Social Dominance in Mice Exposed to a Low Dose of Dioxin in utero and via lactation. PLoS One, 7, e50741.
Watakabe, A., Kato, S., Kobayashi, K., Takaji, M., Nakagami, Y., Sadakane, O., Ohtsuka, M., Hioki, H., Kaneko, T., Okuno, H., Kawashima, T., Bito, H., Kitamura, Y. and Yamamori, T. Visualization of the cortical projection neurons by retrograde TET-OFF lentiviral vector. PLoS One, 7, e46157.
[2011]
Tse, D; Takeuchi, T; Kakeyama, M; Kajii, Y; Okuno, H; Tohyama, C; Bito, H; Morris, RGM. Schema-dependent gene activation and memory encoding in neocortex. Science, 333, 891-895.
Okuno, H. Regulation and function of immediate-early genes in the brain: beyond neuronal activity markers. Neuroscience Res., 69, 175-186.
Komatsu, T., Johnsson, K., Okuno, H., Bito, H., Inoue, T., Nagano, T., and Urano, Y. Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling (FAPL) method. JACS, 133, 6745-6751,
[2010]
Inoue, M., Yagishita-Kyo, N., Nonaka, M., Kawashima, T., Okuno, H. and Bito, H. Synaptic activity-responsive element (SARE): A unique genomic structure with an unusual sensitivity to neuronal activity. Commun Integr Biol., 3, 443-446.
Takemoto-Kimura, S., Suzuki, K., Kamijo, S., Ageta-Ishihara, N., Fujii, H., Okuno, H. and Bito, H. Differential roles for CaM kinases in mediating excitation-morphogenesis coupling during formation and maturation of neuronal circuits. Eur J Neurosci., 32, 224-230.
Redondo, R.L., Okuno, H., Spooner, P.A., Frenguelli, B.G., Bito, H. and Morris, R.G.M. Synaptic tagging and capture: differential role of distinct calcium-calmodulin kinases in protein synthesis-dependent long-term potentiation. J. Neurosci., 30, 4981-4989.
[2009]
Ageta-Ishihara, N., Takemoto-Kimura, S., Nonaka, M., Adachi-Morishima, A., Kamijo, S., Suzuki, S., Fujii, H., Mano, M., Blaeser, F., Chatila, T.A., Mizuno, H., Hirano, T., Tagawa, Y., Okuno, H. and Bito, H. Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. J. Neurosci. 29, 13720-13729.
Kawashima*, T., Okuno*, H., Nonaka, M., Adachi-Morishima, A., Kyo, N., Okamura, M., Takemoto-Kimura, S., Worley, P., Bito, H. A synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons, Proc. Natl. Acad. Sci. USA, 106, 316-321.
[2008-2003]
Bito, H., Takemoto-Kimura, S., Okuno, H. Activity-dependent gene regulation: How do synapses talk to the nucleus and fine-tune neuronal outputs? in "Molecular Pain" (Zhuo, Min. Ed.) Springer, (2008).
Takemoto-Kimura, S., Ageta-Ishihara, N., Nonaka, M., Adachi-Morishima, A., Mano, T., Okamura, M., Fujii, H., Fuse, T., Hoshino, M., Suzuki, S., Kojima, M., Mishina, M., Okuno, H. and Bito, H. Regulation of dendritogenesis via a lipid raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma. Neuron, 54, 755-770, (2007).
Chowdhury, S., Shepherd, JD., Okuno, H., Lyford, G., Petralia, RS., Plath, N., Kuhl, D., Huganir, RL. and Worley, PF. Arc interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron, 52, 445-459, (2006).
Ohmae, S., Takemoto-Kimura, S., Okamura, M., Adachi-Morishima, A., Nonaka, M., Fuse, T., Kida, S., Tanji, M., Furuyashiki, T., Arakawa, Y., Narumiya, S., Okuno, H., and Bito, H. Molecular identification and characterization of a family of kinases with homology to CaMKI/CaMKIV. J. Biol. Chem., 281, 20427-20439, (2006).
[2003年以前]
Tokuyama*, W., Okuno*, H., Hashimoto, T., Li, Y-X. and Miyashita, Y. Selective zif 268 mRNA induction in the perirhinal cortex of macaque monkeys during formation of visual pair-association memory. J. Neurochem., 81, 60-70, (2002).
Li, Y-X., Hashimoto, T., Tokuyama, W., Miyashita, Y. and Okuno†, H. Spatiotemporal dynamics of brain-derived neurotrophic factor mRNA induction in the vestibulo-olivary network during vestibular compensation. J. Neurosci., 21, 2738-2748, (2001).
Li, Y-X., Tokuyama, W., Miyashita, Y., Okuno, H. and Hashimoto, T. Differential induction of brain-derived neurotrophic factor mRNA in rat inferior olive subregions following unilateral labyrinthectomy. Neuroscience, 106, 385-394, (2001).
Tokuyama*, W., Okuno*, H., Hashimoto, T., Li, Y-X. and Miyashita, Y. BDNF upregulation during declarative memory formation in the monkey inferotemporal cortex. Nature Neurosci., 3, 1134-1142, (2000).
Hashimoto, T., Okuno, H., Tokuyama, W., Li, Y-X. and Miyashita, Y. Expression of brain-derived neurotrophic factor, neurotrophin-3 and their receptor messenger RNAs in monkey rhinal cortex. Neuroscience, 95, 1003-1010, (2000).
Okuno, H., Tokuyama, W., Li, Y-X., Hashimoto, T. and Miyashita, Y. Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito-temporo-hippocampal pathway in adult macaque monkeys. J. Comp. Neurol., 408, 378-398, (1999).
Tokuyama, W., Hashimoto, T., Li, Y-X., Okuno, H. and Miyashita, Y. Quantification of neurotrophin-3 mRNA in the rat hippocampal subregions using the RT-PCR-based coamplification method. Brain Res.Protocols, 4, 407-414, (1999).
Tokuyama, W., Hashimoto, T., Li, Y-X., Okuno, H. and Miyashita, Y. Highest trkB mRNA expression in the entorhinal cortex among hippocampal subregions in the adult rat: contrasting pattern with BDNF mRNA expression. Mol. Brain Res., 62, 206-215, (1998).
Okuno, H., Kanou, S., Tokuyama, W., Li, Y-X. and Miyashita, Y. Layer-specific differential regulation of transcription factors Zif268 and JunD in visual cortex V1 and V2 of macaque monkeys. Neuroscience, 81, 653-666, (1997).
Sato, T., Tokuyama, W., Miyashita, Y. and Okuno†, H. Temporal and spatial dissociation of expression patterns between Zif268 and c-Fos in rat inferior olive during vestibular compensation. NeuroReport, 8, 1891-1895, (1997).
Okuno, H. and Miyashita, Y. Expression of the transcription factor Zif268 in the temporal cortex of monkeys during visual paired associate learning. Eur. J. Neurosci., 8, 2118-2128, (1996).
Miyashita, Y., Okuno, H., Tokuyama, W., Ihara, T. and Nakajima, K. Feedback signal from medial temporal lobe mediates visual associative mnemonic codes of inferotemporal neurons. Cognitive Brain Res., 5, 81-86, (1996).
Okuno, H., Saffen, D. W. and Miyashita, Y. Subdivision-specific expression of Zif268 in hippocampal formation of the macaque monkey. Neuroscience, 66, 829-845, (1995).
Okuno, H., Akahori, A., Sato, H., Xanthoudakis, S., Curran, T. and Iba, H. Escape from redox regulation enhances the transforming activity of Fos. Oncogene, 8, 695-701, (1993).
Miyashita, Y., Date, A. and Okuno, H. Configurational encoding of complex visual forms by single neurons of monkey temporal cortex. Neuropsychologia, 31, 1119-1131, (1993).
Miyashita, Y., Okuno, H. and Hasegawa, I. Tuning and association: Neural memory mechanisms of complex visual form in monkey temporal cortex. Biomedcal. Res., 14, suppl. 4, 89-94, (1993).
Miyashita, Y., Sakai, K., Okuno, H., Tanatsugu, Y. and Ninomiya Y. Neural mechanisms of the pictorial long-term memory in the primate temporal cortex.. in "Brain Mechanisms of Perception and Memory" T.Ono, L.R.Squire et al., Eds., p397-404, Oxford University Press, New York., (1992).
Okuno, H., Suzuki, T., Hashimoto, Y., Curran, T. and Iba, H. Inhibition of jun transformation by a mutated fos gene: design of an anti-oncogene. Oncogene, 6, 1491-1497, (1991).
Suzuki, T., Okuno, H., Yoshida, T., Endo, T., Nishina, N. and Iba, H. Difference in transcriptional regulatory function between c-Fos and Fra-2. Nucleic Acids Res., 19, 5537-5542, (1991).
Suzuki, T., Hashimoto, H., Okuno, H., Sato, H., Nishina, H. and Iba, H. High-level expression of human c-jun gene causes cellular transformation of chicken embryo fibroblasts. Jpn. J. Cancer Res., 82, 58-64, (1991).
＜著作物＞
奥野浩行, Single-cell RNA-Seq ②（試薬編）, In "RNA-Seq マスターブック" 鈴木譲編, 羊土社、p.166-173, (2016).
Okuno, H., Araki, A., Minatohara, K. Inverse synaptic tagging by Arc. In "Novel Mechanisms of Memory" Giese, K.P. & Radwanska, K., eds., p.99-118, Springer (2016)
Okuno, H., Neuroplasticity In "Homeostatic control of brain function" Masino, SA. & Boison, D, eds., p.174-186, Oxford University Press, (2015).
Okuno, H., Smythies, JR., and Edelstein, LR. Chapter "Selected key areas for future research on the claustrum" in The Claustrum pSmythies, J., Edelstein L., & Ramachandran, V.S., eds., p363-376, Elsevier, (2014).
奥野浩行、藤井哉、尾藤晴彦. "情報素子としてのシナプス-構造・機能ならびに新たな疾患制御標的としての意義-". in ナノメディシン宇理須恒雄 編 p220-233、オーム社、東京, (2008).
奧野浩行. "側頭葉における長期記憶と遺伝子発現", in 側頭葉、 板倉徹、前田敏博 編、p51－70 ブレーン出版、東京, (1997).
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